Search results for "Molecular screening"

showing 4 items of 4 documents

First Nationwide Molecular Screening Program in Spain for Patients With Advanced Breast Cancer: Results From the AGATA SOLTI-1301 Study

2021

Anàlisi de seqüències d'ADN; Subtipus PAM50; Genètica molecular Análisis de secuencias de ADN; Subtipo PAM50; Genética molecular DNA sequence analyses; PAM50 subtype; Molecular genetic Background: The SOLTI-1301 AGATA study aimed to assess the feasibility of a multi-institutional molecular screening program to better characterize the genomic landscape of advanced breast cancer (ABC) and to facilitate patient access to matched-targeted therapies in Spain. Methods: DNA sequencing of 74 cancer-related genes was performed using FFPE tumor samples in three different laboratories with three different gene panels. A multidisciplinary advisory board prospectively recommended potential targeted trea…

OncologyCancer ResearchDNA Alterationmedicine.medical_specialtymolecular targeted therapyAdvanced breast:Neoplasms::Neoplasms by Site::Breast Neoplasms [DISEASES]Cancer therapy:terapéutica::farmacoterapia::terapia molecular selectiva [TÉCNICAS Y EQUIPOS ANALÍTICOS DIAGNÓSTICOS Y TERAPÉUTICOS]:Therapeutics::Drug Therapy::Molecular Targeted Therapy [ANALYTICAL DIAGNOSTIC AND THERAPEUTIC TECHNIQUES AND EQUIPMENT]Breast cancerbreast cancerInternal medicineGene panelmolecular geneticmedicineDNA sequence analysesRC254-282Original ResearchFarmacologia molecular:neoplasias::neoplasias por localización::neoplasias de la mama [ENFERMEDADES]:Natural Science Disciplines::Biological Science Disciplines::Biology::Computational Biology::Genomics [DISCIPLINES AND OCCUPATIONS]Molecular screeningbusiness.industryCancerNeoplasms. Tumors. Oncology. Including cancer and carcinogensmedicine.diseaseOncologyMama - Càncer - Tractament:disciplinas de las ciencias naturales::disciplinas de las ciencias biológicas::biología::biología computacional::genómica [DISCIPLINAS Y OCUPACIONES]Mama - Càncer - Aspectes molecularsPAM50 subtypebusiness
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Primary results of the first nationwide molecular screening program in Spain for patients with advanced breast cancer (AGATA SOLTI-1301 study)

2018

Oncologymedicine.medical_specialtyMolecular screeningbusiness.industryAdvanced breastCancerHematologymedicine.diseaseBreast cancerOncologyInternal medicinemedicineAGATAbusinessAnnals of Oncology
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The DrosDel Collection

2004

Abstract We describe a collection of P-element insertions that have considerable utility for generating custom chromosomal aberrations in Drosophila melanogaster. We have mobilized a pair of engineered P elements, p{RS3} and p{RS5}, to collect 3243 lines unambiguously mapped to the Drosophila genome sequence. The collection contains, on average, an element every 35 kb. We demonstrate the utility of the collection for generating custom chromosomal deletions that have their end points mapped, with base-pair resolution, to the genome sequence. The collection was generated in an isogenic strain, thus affording a uniform background for screens where sensitivity to genetic background is high. The…

Set (abstract data type)Whole genome sequencingGeneticsP elementbiologyMolecular screeningStrain (biology)GeneticsDrosophila melanogasterbiology.organism_classificationSelection (genetic algorithm)Sequence (medicine)Genetics
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Application of molecular topology to the prediction of antiparasitic activity against Giardia intestinalis and Trichomonas vaginalis of 2-Acylamino-n…

2020

Giardia intestinalis y Trichomonas vaginalis destacan por su importancia clínica. G. intestinalis causa la giardiosis, una parasitosis de gran importancia epidemiológica y clínica por presentar una elevada prevalencia. T. vaginalis causa la tricomoniasis, la enfermedad de transmisión sexual (ETS) no viral con mayor incidencia del mundo. Ambas parasitosis comparten el mismo tratamiento farmacológico: los nitroimidazoles. Se ha aplicado la topología molecular en la búsqueda de derivados del 2-Acylamino-nitro-1,3-tiazol con actividad antiparasitaria frente a G. intestinalis y T. vaginalis . Con el análisis lineal discriminante se obtuvo un modelo capaz de clasificar correctamente el 92,85 % de…

Sexually transmitted diseasePharmacologyHigh prevalenceMolecular topologyGiardiosisMolecular screeningTopología molecularBiologymedicine.disease_causeMolecular biologyPharmacological treatment2302.22 Farmacología MolecularFármacosmedicineTrichomonas vaginalisMultiple linear regression analysisParasitologíaParasitologyMolecular topology
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